Clinical Studies

Validated to Lower Blood Pressure in 10 Clinical Studies

• Ten clinical studies with peer-reviewed, published results have assessed the safety and efficiency of lowering high blood pressure in patients, whether taking medication or not.
• Over 200,000 users prior to NHS decision to include on UK's drug tariff.

Studies design:

• Clinical studies design included five randomized controlled trials, ^{1,2,5, 7}one controlled⁴ and four open-label.^{3,6, 8,9}
• The controlled studies compared 8-week 15-minute daily treatment with RESPeRATE with control group, using Walkman with relaxing music¹, home blood pressure monitor^4,5 or both².
• There were a total of 507 participants, mean age of 58 (25 to 75); 78% on antihypertensive medication, of whom 1/3 on 3 or more medications.
• Average initial office blood pressure was 150/90 mmHg despite other therapies, diet, exercise and/or medications.

Studies results:

• RESPeRATE users with uncontrolled blood pressure experienced a significant decrease in office blood pressure with mean reduction of 14/8 mmHg (versus 9/4 mmHg in control), independently of gender and medication status.
• Greater reductions for older patients (18/8 mmHg for age>65). ¹⁰
• Of patients classified as stage 1 and 2, 46% and 26% achieved the blood pressure goal (<140/90 mmHg), respectively.¹¹
• The drop in office blood pressure displayed dose-response relationship with the duration of slow breathing: Those who used RESPeRATE more achieved greater reductions.⁵
• A clinically significant sustained reduction in blood pressure typically occurred in 3 to 4 weeks.
• Effective for resistant hypertension,⁶ isolated systolic hypertension,⁵ diabetes with hypertension⁷ and white-coat hypertension.¹²
• All-day, lasting blood pressure lowering effect observed at the clinic, ^1-9 home,^{2-4, 6} and with 24-hour ambulatory blood pressure measurements.^3,9 Benefit and compliance were demonstrated over 6-month follow up. ¹³
• No observed side effects.^1-9

See Indications and administration guidelines >>

RESPeRATE Peer-Reviewed Articles

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